doi: 10.1038/clpt.2009.167
Paul, C
During HBs specification, the pioneer factors recruit EZH2, a histone methyltransferase (KMTs) that catalyzes histone three lysine 27 (H3K27) me3, to silent pancreatic-specific genes in HBs (Tachmatzidi et al., 2021), which exerts unique functions in liver-specific gene activation by interacting and travelling with RNA polymerase II from the distal to proximal regions of transcription start sites (Lau et al., 2018), which recruits RNA polymerase II to hepatic genes during liver bud formation (Tachmatzidi et al., 2021), which maintains hepatocyte identity and metabolic functions together with FOXA, TBX3, and CEBP (Kotulkar et al., 2023)
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