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Cigarette smoke contains chemicals that may cause several disorders, including cardiovascular disease, cancer, and chronic obstructive pulmonary disease

Some protocols use longer cycles or maintenance dosing

Even those who eat meat, or supplement with B12 may still be deficient due to inadequate intake

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Because of its anti-androgenic activity and the requirement of testosterone for male morphogenesis, spironolactone may have the potential for adversely affecting sex differentiation of the male during embryogenesis