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Additionally a meta-analysis found use of GLP-1RA was associated with higher risk of gallbladder and biliary disease with high doses for longer duration (113)
In the study, participants with a responsive genetic score had an 82% increase in the likelihood of acheiving weight loss with a GLP-1 medication.[ref] Another study showed that GLP1 receptor variants are associated with greater weight loss on GLP-1 RA drugs.[ref] Common genetic variants in the GLP1R (GLP-1 receptor) gene impact weight and type 2 diabetes risk
Dehydration and Metabolic Changes GLP-1 users often experience dehydration and metabolic shifts, which can affect the skins ability to bounce back
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In the published Mounjaro trials, roughly 25-30% of total weight loss is from lean mass, including muscle
