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Moreover, the applicant provided that, of the 2.2 million flexible cystoscopy procedures furnished annually, 23 percent are performed with single-use, disposable cystoscopes, further, single-use, disposable cystoscopes are used in at least 500 hospitals and clinics, including 35 to 50 academic medical centers

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Based on the 16S rRNA gene, the dominant isolate from the simulation experiment had a 99.1% homology to Pseudodesulfovibrio aespoeensis Aspo-2 (DSM 10631 T), which was isolated from granitic groundwater sampled at a depth of 600 m (611 MPa) (Motamedi and Pedersen, 1998)

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Second, the doses are small because the target is a high-affinity intracellular enzyme, not a receptor that needs saturating with milligrams of drug