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Achieving and maintaining significant weight loss can lead to substantial improvements in these comorbidities, reducing healthcare burdens and enhancing overall health outcomes

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Future studies should validate these targets in preclinical models and explore their translational potential to develop interventions improving the outcomes of patients with SAE

Patients received oral semaglutide or matching placebo at 3 mg for 4 weeks, followed by 7 mg for 4 weeks, then 14 mg for the remainder of the study