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Therefore, the aforementioned novel applications of GLP-1RAs all have the potential to bolster treatment and management options for the field as a whole, and new research continues to illuminate the physiological mechanisms behind this observed neuroprotective effect

They identified gastrointestinal (GI) issues, particularly vomiting and nausea, as the most common side effects for most GLP-1 RAs, while headache and joint pain were most frequently discussed in posts about tirzepatide

7 In patients who meet these criteria, the ADA preferably recommends use of a GLP-1 RA with proven cardiovascular benefit or an SGLT-2 inhibitor with proven cardiovascular benefit provided they have adequate kidney function

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The study population was relatively small and predominantly female, thus potentially limiting our ability to assess effect size across sex