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86, 87 Similarly, IL-6 modulation of the claudin-2 gene induces intestinal epithelial TJ permeability through the JNK pathway

The mechanism linking these effects is well-documented in the growth hormone literature

Stress alone does not cause postmenopausal bleeding

While supplementing with large doses of B12 will reduce MMA levels more than will smaller doses, there are no clear benefits (more info in Appendix A

Researchers set out to find an adequate dose at that age, and it seems we need at least about 650 to 1,000 a day in most people, hence my 1,000-a-day recommendation after age 65